4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is a specialized pharmaceutical intermediate with CAS number 570407-42-0. This compound features a unique structure combining thiazole, chlorothiophene, and cyclohexylpiperazine moieties, making it a valuable building block in drug discovery and development. The molecular formula is C17H23ClN4S2 with a molecular weight of 382.97 g/mol. The predicted boiling point is 560.0+/-50.0C with a density of 1.345+/-0.06 g/cm3. The pKa value is approximately 7.58+/-0.70. This compound is primarily used as an intermediate in the synthesis of thrombopoietin receptor agonists, specifically Avatrombopag. Avatrombopag is a thrombopoietin receptor agonist used to treat thrombocytopenia (low platelet count) in patients with chronic liver disease or immune thrombocytopenia. The compound also appears as an impurity in Avatrombopag pharmaceutical preparations, including various related compounds such as Avatrapa impurity 10, Avatroposide impurities, Avatrombopag Impurity 47, and Avatrombopag Impurity 13. Safety considerations include that this product is intended for non-medical purposes such as industrial applications or scientific research only. It cannot be used for clinical diagnosis or treatment of humans or animals and is not medicinal or edible. Purchase of hazardous materials requires valid qualifications. The compound is synthesized from the reaction of 4-(4-Chloro-2-thienyl)-5-bromo-2-thiazolylamine with cyclohexylpiperazine. Global suppliers number 79, with 78 from China and 1 from India.