5-Acetyl-1H-pyrazole-3-carboxylic acid

5-Acetyl-1H-Pyrazole-3-carboxylic acid is a crucial pharmaceutical intermediate with CAS number 1297537-45-1. This compound serves as a key building block in organic synthesis and medicinal chemistry, particularly in the manufacture of Darolutamide, an anti-androgen medication developed by Orion Corporation and Bayer Health Care for the treatment of prostate cancer in men. The molecular formula is C6H6N2O3 with a molecular weight of 154.12 g/mol. Physically, it appears as a solid compound with a melting point of 257-269C (with decomposition). The compound has a density of 1.467+/-0.06 g/cm3 and a pKa value of 3.60+/-0.10. In terms of safety, this compound is classified with GHS07 warning symbols. Hazard statements include H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate precautionary measures should be taken when handling this material. The compound is synthesized through a multi-step process from hydrazine and acetyl chloride. A safe and metal-free process using ethyl glycinate hydrochloride as the starting material has been developed, achieving a yield of 63 grams with 99.93% purity as determined by HPLC. Applications include industrial applications in polyurethane manufacturing, pharmaceutical intermediate usage for Darolutamide synthesis, valuable building blocks for organic and medicinal chemistry transformations, and drug development research. This compound is primarily supplied from China with 122 suppliers globally, as well as suppliers in India, Russia, and the United States.